There is a great need to be careful about the use and over reliance
upon docking studies to predict in-vivo effect. Curcumin is
thought to exist only in the enol form when dissolved in water.
Thus only the enol variant should be used for docking.
Many targets were selected for myeloma and curcumin was one of the
many drugs selected for docking study. One target being GADD45B is
given as an example in the Myeloma page although that docking is with the Green Tea phenol EGCG
The docking studies are well and good but the real problem then
arises that if one decides it would be good to get a curcumin molecule
into the bone marrow then how on earth do you do it. It is a long
fraught path from mouth to bone marrow. Stomach acid and intestine
alkalinity along with water are potential degradation chemicals.
Intestinal absorption is a whole topic and blood transfer complex.
However a starting position for any drug application must be than the
intestinal absortion size must be below 100nm and blood transport via
albumin must be single molecules in solution. This gives curcumin
an immediate problem because the blood levels for oral consumption of
very high doses as shown below are below 4uM and most of the time around
This must be considered in the light of the effective doses as illustrated below.
Curcumin solubility in water is approximately 3mg per litre.
Even with maximum intestinal absorption the 5 litres of blood we have
could only hold 15mg dissolved.
By enclosing single molecules of curcumin ( very hydrophobic) in
molecules such as vinylpyrollidone ( very hydrophillic ) we appear to be
able to deliver amorphous curcumin into solution. My most rapid and
concentrated solutions resulted from ( by mass) 1 part of curcumin and 7
parts of vinylpyrollidone.
For further details search and refer to "Comparative study of curcumin and curcumin formulated in a solid dispersion - Evaluation of their antigenotoxic effects"
Here we are talking about major changes to the delivery of curcumin. I refer you to Brad Culkin's site.
I find the technique unexplainable , unlikely and of profound
effect. The site may be a little out-of-date in the detail but the basics seem
to provide for a concentrated and protected delivery of curcumin to the